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Pharmaceutical Dosage Form and Technology(药物剂型与工艺)(张奇)

Pharmaceutical Dosage Form and Technology(药物剂型与工艺)(张奇)

  • 作者
  • 张奇 主编

《Pharmaceutical Dosage Form and Technology(药物剂型与工艺)》通过介绍药物剂型和药物载体系统的处方、制备工艺过程、科学原理和临床应用特点等,使读者初步了解药物制剂与工艺的基本原理、剂型设计、处方筛选以及不同药物剂型的临床应用等知识,还可以对一些制剂的最新、最前沿研究成果有所了解。本书共10章:第1章是基础知识介绍;第2章和第3章是固体药物...


  • ¥68.00

ISBN: 978-7-122-38090-6

版次: 1

出版时间: 2021-04-01

图书介绍

ISBN:978-7-122-38090-6

语种:英文

开本:16

出版时间:2021-04-01

装帧:精

页数:193

图书前言

《Pharmaceutical Dosage Form and Technology(药物剂型与工艺)》介绍了一些有代表性的药物剂型和药物载体系统,通过对药物剂型和药物载体系统的处方、制备工艺过程、科学原理和临床应用特点等的介绍,使读者初步了解药物制剂与工艺学的基本原理、剂型设计、处方筛选以及不同药物剂型的临床应用等知识。
本书英语语言准确、表达流畅、内容精炼、通俗易懂、贴合实际教学。另外,药物制剂领域中最新、最前沿的研究成果在本书中也有介绍。
本书由北京理工大学化学与化工学院制药工程系张奇主编。内容包括10章:第1章是基础知识介绍(张奇编写);第2章和第3章是固体药物制剂,在这两章中,除了对固体制剂基本内容的介绍外,还对制粒工艺和包衣工艺进行了重点讲述(刘方,Kavil Patel,张奇编写);第4章和第5章分别是肺部用药系统和透皮药物运载系统,介绍了该领域的前沿工艺和技术(金义光,杜丽娜,李淼编写);第6章和第7章分别是液体制剂和无菌制剂,包括混悬液、乳剂、注射剂等剂型(杨子毅,林霞编写);第8章是口服载药系统和该领域的最新研究成果(张宇编写);第9章是栓剂(张奇编写);第10章是有关儿童患者和老年患者临床用药注意事项(刘方编写)。
本书的编写人员由国内外高校药物制剂专业的一线专任教师和研究所的药物制剂科研工作人员组成,这些专家不仅在教学和科研工作中积累了丰富的经验和素材,而且能够敏锐捕捉和跟踪该领域最新国际前沿,使本书内容有较强的实用性和新颖性。
本书获批北京理工大学2020年“特立”系列教材,并得到了北京理工大学教育经费的资助,在本书的编写过程中还得到了学校和学院领导的关心和支持,在此深表感谢。
编者们虽然在编写过程中尽了最大努力,但书中还是难免有疏漏之处,诚恳希望广大读者在使用本书有所收获的同时,将体会和批评指正意见反馈给我们,使本书不断完善、修正和提高。

张奇
2020年6月


This is the first edition of Pharmaceutical Dosage Form and Technology. 
The purpose of this book is to introduce some representative dosage forms and drug delivery systems, which include the definition, excipients, manufacturing process and scientific principle underlying the preparation of them. 
This book can be used as textbook for pharmaceutical sciences undergraduate students. It can also be used as the reading book for pharmaceutical sciences/pharmacy related subject undergraduate students and pharmaceutical sciences graduate students. 
This book consists of ten chapters. The first chapter is introduction of the basic knowledge of drug and pharmacy. The second chapter is an overview of solid dosage forms. The third chapter is focused on the granulation process and the fourth chapter is on film coating technology. The fifth chapter is pulmonary drug delivery systems and the sixth chapter is transdermal drug delivery system. Some frontier and advanced dosage forms and the technologies are shown in these two chapters. The seventh chapter introduces different liquid dosage forms such as suspension and emulsion. The eighth chapter is for the sterilized preparations. The chapter nine is about modified-release oral drug delivery including current advancement in this field. Chapter ten is regarding suppositories as drug delivery dosage forms. The eleventh chapter is the last chapter and focuses on considerations in dosage form application to the pediatric and geriatric patients.
The authors of this book consist of professors from different pharmaceutical universities with strong academic backgrounds. 
I acknowledge with grateful appreciation to the writers of this book and especially thank to the funding from Beijing Institute of Technology, which support the publication of this book.
Nevertheless, some inaccuracy might occur in this book, which we will endeavor to improve and correct in the future. We hope that readers will find this book valuable and we appreciate your opinions during you using this book to continuously improve its quality and accuracy. 

Qi Zhang
2020.06

精彩书摘

《Pharmaceutical Dosage Form and Technology(药物剂型与工艺)》通过介绍药物剂型和药物载体系统的处方、制备工艺过程、科学原理和临床应用特点等,使读者初步了解药物制剂与工艺的基本原理、剂型设计、处方筛选以及不同药物剂型的临床应用等知识,还可以对一些制剂的最新、最前沿研究成果有所了解。本书共10章:第1章是基础知识介绍;第2章和第3章是固体药物制剂;第4章和第5章分别是肺部用药系统和透皮药物运载系统;第6章和第7章分别是液体制剂和无菌制剂;第8章是口服载药系统和该领域的最新研究成果;第9章是栓剂;第10章是有关儿童患者和老年患者临床用药注意事项。本书内容精炼、通俗易懂、英语语法准确,贴合实际教学需求,有助于提高学生专业英语水平。
本书可以作为药学类专业本科生或研究生药物制剂与工艺学及相关课程的教材,也可以作为药学相关领域科研人员的参考书。

目录

Chapter 1 Introduction	1
1.1 Drugs and diseases	1
1.1.1 Treatment of diseases	1
1.1.2 Drug substances and medicines	1
1.1.3 The history of drugs	2
1.1.4 The drug-target interaction	3
1.2 About pharmacy	5
1.2.1 Pharmaceutical sciences	5
1.2.2 Pharmaceutics	5
1.2.3 Dosage forms and drug delivery systems	6
1.2.4 Categories of DDS	9
1.3 The standardization of medicine	11
1.3.1 Why medicine needs standard	11
1.3.2 Pharmacopeia	12
1.4 Clinical using medicine	12
1.4.1 Brand medicine and generic medicine	12
1.4.2 Prescription medicine and over-the-counter medicine	13
1.4.3 Prescription	13
1.4.4 Drug-drug interaction	14
1.4.5 Drug-food interaction	14
References	16

Chapter 2 Solid dosage forms I	17
2.1 Introduction	17
2.2 Powder	18
2.3 Granules	20
2.3.1 Preparation of granules	22
2.3.2 Granulation methods and equipments	22
2.3.3 Quality control of granules	31
References	33

Chapter 3 Solid dosage forms II	34
3.1 Capsules	34
3.1.1 Hard gelatin capsules	34
3.1.2 Soft capsules	36
3.2 Tablets	37
3.2.1 Excipients of tablets	39
3.2.2 Manufacture of tablets	40
3.2.3 Film coating	42
3.2.4 Quality control of tablets	53
3.2.5 Packaging and storing of tablets	58
References	59

Chapter 4 Pulmonary drug delivery system	60
4.1 Introduction	60
4.1.1 Anatomy of lungs	60
4.1.2 Advantages of pulmonary drug delivery	61
4.1.3 Mechanisms of particle deposition in the lung	62
4.2 Pulmonary drug delivery devices	62
4.2.1 Nebulizers	63
4.2.2 pMDIs	64
4.2.3 DPIs	64
4.2.4 Soft mist inhaler	65
4.3 Factors governing aerosol deposition and targeting in the lung	66
4.3.1 Aerodynamic diameter and size distribution	66
4.3.2 Airflow rate	66
4.3.3 Particle shape	67
4.3.4 Particle density	67
4.3.5 Surface roughness	67
4.4 Clinical application of pulmonary drug delivery systems	68
4.5 Perspectives of pulmonary drug delivery	69
References	70

Chapter 5 Transdermal drug delivery system	73
5.1 Introduction	73
5.2 Skin structure and the major obstacles of transdermal permeation	74
5.3 Major transdermal routes	75
5.3.1 Appendageal routes	75
5.3.2 Transcellular routes	75
5.3.3 Intercellular routes	75
5.4 Chemical penetration enhancers	76
5.4.1 Natural chemical penetration enhancers	76
5.4.2 Synthetic chemical penetration enhancers	77
5.4.3 Combination of penetration enhancers	82
5.5 Physical techniques to improve transdermal delivery	83
5.5.1 Microneedle	83
5.5.2 Laser	84
5.5.3 Iontophoresis	86
5.5.4 Sonophoresis	87
5.5.5 Electroporation	89
5.5.6 Magnetophoresis	90
5.5.7 Microwave	90
5.6 Transdermal formulations	91
5.6.1 Liposome	91
5.6.2 Cubic phase	91
5.6.3 Microemulsion	91
5.6.4 Hydrogel	91
5.6.5 Transfersome	92
5.7 Device-assisted or wearable transdermal delivery systems	92
5.7.1 Development stages	92
5.7.2 Device	93
5.7.3 Application	94
5.7.4 Prospect	94
References	94

Chapter 6 Liquid dosage forms	101
6.1 Introductions	101
6.1.1 Solubilities	101
6.1.2 Solvents	102
6.1.3 Enhancements	103
6.2 Syrups	103
6.3 Elixirs	104
6.4 Suspensions	105
6.4.1 Sedimentation of particles in suspension	105
6.4.2 Preparation of suspensions	107
6.4.3 Colloidal dispersions	108
6.5 Emulsions	109
6.5.1 Pharmaceutical emulsions	110
6.5.2 Emulsion formation theory	111
6.5.3 Emulsion identification	112
6.5.4 Emulsion preparation	112
6.5.5 The HLB system	116
6.5.6 Emulsion stability	117
6.5.7 Nanoemulsions	120
6.6 Creams	121
6.7 Gels and magmas	122
References	123

Chapter 7 Sterilized preparations	124
7.1 Principles of sterilization	124
7.1.1 Introduction	124
7.1.2 Sterilization parameters	124
7.1.3 Principles of sterilization processes	125
7.1.4 Gaseous sterilization	127
7.1.5 Radiation sterilization	128
7.1.6 Filtration sterilization	129
7.1.7 High-level disinfection	129
7.2 Parenteral	130
7.2.1 Introduction	130
7.2.2 Injections	130
7.2.3 Large-volume parenterals	131
7.3 Biologics	131
7.3.1 Introduction	131
7.3.2 Types of immunity	132
7.3.3 Production of biologics	132
7.4 Ophthalmic solution and suspensions	133
7.4.1 Introduction	133
7.4.2 Pharmaceutical requirements	134
References	136

Chapter 8 Modified-release oral drug delivery	138
8.1 Introduction of modified-release oral drug delivery	138
8.1.1 Sustained-release preparation	138
8.1.2 Controlled-release preparation	138
8.1.3 Delayed-release preparation	138
8.2 Theories of extended-release oral drug delivery	139
8.2.1 Theory of dissolution-controlled	139
8.2.2 Theory of diffusion-controlled	140
8.2.3 Combination of erosion and diffusion theory	141
8.2.4 Osmotic pressure theory	142
8.2.5 Ion exchange theory	143
8.3 Design of extended-release oral drug delivery systems	144
8.3.1 Properties of drugs	144
8.3.2 Design requirements	147
8.4 Quality assessment	149
8.4.1 In vitro assessment	149
8.4.2 In vivo assessment	150
8.4.3 In vitro correlation	150
8.5 Application of extended-release oral drug delivery systems	154
8.6 Oral chronopharmacologic and oral site-specific drug delivery system	160
8.6.1 Overview	160
8.6.2 Theories	161
8.6.3 Brief introductions	163
8.6.4 Applications	166
References	171

Chapter 9 Suppositories	173
9.1 Introduction	173
9.2 Suppository bases	174
9.2.1 Fatty or oleaginous bases	174
9.2.2 Water-soluble or water-miscible bases	174
9.3 Preparation of suppositories	175
9.3.1 Manufacturing procedure	175
9.3.2 Displacement value	176
9.3.3 Quality control	177
9.3.4 Examples	177
9.4 Packing and storage	178
9.5 Special types of suppositories	178
References	179

Chapter 10 Paediatric and geriatric drug developent	180
10.1 Introduction	180
10.2 Physiological changes	180
10.3 Excipient safety	181
10.4 Taste	183
10.5 Formulation choices	184
10.5.1 Tablets	184
10.5.2 Liquids	185
10.5.3 Multiparticulates	186
10.5.4 Dispersible and orally dispersible formulations	186
10.5.5 Chewable tablets	187
References	188

Indexes	190

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